Research Publications

Collier, C.L., Ruedi, C., Thorne, N.J., and Tumbarello, D.A. (2025) “PINK1 Loss of Function Selectively Alters the Mitochondrial-Derived Vesicle Pathway.” FASEB BioAdvances 7: e70030.

Thorne, N.J. and Tumbarello, D.A. (2022) “The relationship of alpha-synuclein to mitochondrial dynamics and quality control.” Front Mol Neurosci 15:947191.

Minton A.R., Smith L.D., Bryant D.J., Strefford J.C., Forconi F., Stevenson F.K., Tumbarello D.A., James E., Løset G.Å., Munthe L.A., Steele A.J., Packham G. (2022) “B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells.” Explor Target Antitumor Ther. Feb 25; 3:37-49.

Capelluto, D., Conde, C. B., Tumbarello, D. A., & van den Bogaart, G. (2021) “Editorial: Signaling Proteins for Endosomal and Lysosomal Function.” Front Cell Dev Biol 9, 821719.

Caetano, L., Eckert, J., Johnston, D., Chatelet, D., Tumbarello, D.A., Smyth, N., Ingamells, S., Price, A., and Fleming, T.F. (2021) “Blastocyst trophectoderm endocytic activation, a marker of adverse developmental programming.” Reproduction 162(4), 289-306.

Cooke, L.D.F., Tumbarello, D.A., Harvey, N.C., Sethi, J.K., Lewis, R.M., Cleal, J.K. (2021) “Endocytosis in the placenta: An undervalued mediator of placental transfer.” Placenta May 3; S0143-4004(21)00140-5.

Ryan, T.A. and Tumbarello, D.A. (2021) “A central role for mitochondrial-derived vesicles in the innate immune response: implications for Parkinson’s disease.” Neural Regen Res 16(9):1779-1780.

Keeling, E., Chatelet, D.S., Tan, N.Y.T., Khan, F.; Richards, R., Thisainathan, T., Goggin, P., Page, A., Tumbarello, D.A., Lotery, A.J., Ratnayaka, J.A. (2020) “3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina.” Int J Mol Sci 21(21): 8408.

Keeling, E., Culling, A.J., Johnston, D.A., Chatelet, D.S., Page, A., Tumbarello, D.A., Lotery, A.J., Ratnayaka, J.A. (2020) “An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy.” Int J Mol Sci 21(18): 6647.

Assar, E.A. and Tumbarello, D.A. (2020) “Loss of the essential autophagy regulators FIP200 or Atg5 leads to distinct effects on focal adhesion composition and organisation.” Front Cell Dev Biol Aug 4; 8:733.

Ryan, T. A., Phillips, E.O., Collier, C.L., Robinson, A.J.B., Routledge, D., Wood, R.E., Assar, A.A., and Tumbarello, D. A. (2020) “Tollip coordinates Parkin-dependent mitochondrial derived vesicle trafficking.” EMBO J Jun 02; 39(11):e102539.

Smith, L.D., Minton, A.R., Blunt, M.D., Karydis, L.I., Dutton, D.A., Rogers-Broadway, K., Dobson, R., Liu, R., Norster, F., Hogg, E., Ashton-Key, M., Strefford, J.C., Jia, L., Efremov, D.G., Helgason, G.V., Johnson, P.W.M., Stevenson, F.K., Forconi, F._, Cragg, M.S., Tumbarello, D.A., Packham, G., Steele, A.J. (2019) “BCR Signaling Contributes to Autophagy Regulation in Chronic Lymphocytic Leukemia.” Leukemia Aug 28:1-5.

Keeling, E., Chatelet, D.S., Johnston, D.A., Page, A., Tumbarello, D.A., Lotery, A.J. and Ratnayaka, J.A. (2019) “Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE).” Molecular nutrition & food research, p.e1800951.

Lynn, S.A., Keeling, E., Dewing, J.M., Johnston, D.A., Page, A., Cree, A.J., Tumbarello, D.A., Newman, T.A., Lotery, A.J. and Ratnayaka, J.A. (2018) “A convenient protocol for establishing a human cell culture model of the outer retina.” F1000Research, 7.

Ryan, T. A. and Tumbarello, D. A. (2018) “Optineurin: a coordinator of membrane-associated cargo trafficking and autophagy. ” Frontiers in Immunology, 9, 1024.

Keeling, E., Lotery, A.J., Tumbarello, D.A., Ratnayaka, J.A. (2018) “Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases.” Cells 7(2), 16.

Lynn, S.A., Ward, G., Keeling, E., Scott, J.A., Cree, A.J., Johnston, D.A., Page, A., Cuan-Urquizo, E., Bhaskar, A., Grossel, M.C., Tumbarello, D.A., Newman, T.A., Lotery, A.J., Ratnayaka, J.A. (2017) “Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE.” Tissue and Cell Jun 19. pii: S0040-8166(17)30064-2.

Masters, T.A., Tumbarello, D.A., Chibalina, M.V., Buss, F. (2017) “Myo6 regulates spatial organisation of signaling endosomes driving Akt activation and actin dynamics.” Cell Reports 19(10), 2088 – 2101.

Tumbarello, D.A.*, Andrews, M.R., Brenton, J.D. (2016) “SPARC Regulates Transforming Growth Factor Beta Induced (TGFBI) Extracellular Matrix Deposition and Paclitaxel Response in Ovarian Cancer Cells.” PLoS ONE 11(9): e0162698. doi:10.1371/journal.pone.0162698   *corresponding author

Arden, S.A., Tumbarello, D.A., Butt, T., Kendrick-Jones, J., Buss, F. (2016) “Loss of cargo-binding in the human myosin VI deafness mutant (R1166X) leads to increased actin filament binding.” Biochem J Jul 29. pii: BCJ20160571.

Andrews, M.R., Soleman, S., Cheah, M., Tumbarello, D.A., Mason, M., Moloney, E.B., Verhaagen, J., Bensadoun, J.C., Schneider, B.L., Aebischer, P., Fawcett, J.W. (2016) “Axonal localization of integrin receptors in the CNS is neuronal subtype and age dependent.” eNeuro 3 (4), ENEURO. 0029-16.2016.

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., […], Tumbarello, D.A., et al. (2016) “Guidelines for the use and interpretation of assays for monitoring autophagy.” Autophagy 12(1), 1-222.

Tumbarello, D.A.*, Manna, P.T., Allen, M.D., Bycroft, M., Arden, S.D., Kendrick-Jones, J., Buss, F.* (2015) “The autophagy receptor TAX1BP1 and the molecular motor myosin VI are required for clearance of Salmonella typhimurium by autophagy.” PLOS Pathogens 11(10): e1005174.
*co-corresponding author

Brandstaetter, H.*, Kishi-Itakura, C.*, Tumbarello, D.A.*, Manstein, D.J., Buss, F. (2014) “Loss of functional myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion.” Autophagy Dec 2; 10(12): 2310-2323.
*these authors contributed equally

Tumbarello, D.A., Kendrick-Jones, J., Buss, F. (2013) “Myosin VI and its cargo adaptors – linking endocytosis and autophagy.” J Cell Sci Jun 15, 126(Pt 12): 2561-70.

Bond, L.M., Tumbarello, D.A., Kendrick-Jones, J., Buss, F. (2013) “Small molecule inhibitors of myosin proteins.” Future Med Chem Jan; 5(1); 41-52.

Tumbarello, D.A.*, Waxse, B.J., Arden, S.D., Bright, N.A., Kendrick-Jones, J., Buss, F.* (2012) “Autophagy-receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.” Nat Cell Biol Sep 30;14(10):1024-35.
*co-corresponding author

Tumbarello, D.A., Temple, J., Brenton, J.D. (2012) “Beta3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells.” Mol Cancer 11(1):36.

Pignatelli, J., Tumbarello, D.A., Schmidt, R.P., Turner, C.E. (2012) “Hic-5 promotes invadopodia formation and invasion during TGF-ß-induced epithelial-mesenchymal transition.” J Cell Biol 197(3): 421-37.

Dabiri, G., Tumbarello, D.A., Turner, C.E., Van De Water, L. (2008) “Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop.” J Invest Dermatol 128(10), 2518-25.

Dabiri, G., Tumbarello, D.A., Turner, C.E., Van De Water, L. (2008) “Autocrine induction of TGF-β1 slows proliferation in pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5.” J Invest Dermatol 128(2), 280-91.

Tumbarello, D. A., Turner, C. E. (2007) “Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway.” J Cell Physiol 211(3), 736-747.

Jamieson, J. S., Tumbarello, D. A., Halle, M., Brown, M. C., Tremblay, M. L., Turner, C. E. (2005) “Paxillin is necessary for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker.” J Cell Sci 118(Pt 24), 5835-47.

Tumbarello, D. A., Brown, M. C., Hetey, S. E., Turner, C. E. (2005) “Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta.” J Cell Sci 118(Pt 20), 4849-63.

Tumbarello, D. A., Brown, M. C., Turner, C. E. (2002) “The paxillin LD motifs.” FEBS Lett 513(1), 114-8.

Book Chapters

Tumbarello, D.A. and Turner C.E. “The Paxillin Family and Tissue Remodeling”, in Cell Junctions: Adhesion, Development, and Disease. Editors S.E. LaFlamme and A. Kowalczyk, Wiley-VCH, 47-60, 2008.